News

Here you will find an archive of news and announcements I have had over my career.

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Coronary manuscript written by medical student Stephan Maman published in the Journal of Applied Physiology.

posted Aug 12, 2017, 5:38 AM by Annie Muller   [ updated Aug 12, 2017, 5:44 AM ]

In this study, we evaluated the role of vascular β1 vs. β2 receptors in coronary exercise hyperemia in a single-blind, randomized, crossover study in healthy men. In response to isometric handgrip exercise, blood flow velocity in the left anterior descending coronary artery was significantly greater with esmolol compared with propranolol. These findings increase our understanding of the individual and combined roles of coronary β1 and β2 adrenergic receptors in humans. Please see the citation on the Research tab.

Near infrared manuscript written by J. Carter Luck published in the Journal of Applied Physiology.

posted Jul 22, 2017, 10:31 AM by Annie Muller

In this laboratory study, patients with peripheral artery disease performed plantar flexion exercise in the supine posture until symptoms of claudication occurred. Relative to age- and sex-matched healthy subjects we found that patients had a higher blood pressure response, a higher heart rate response, and a greater reduction in skeletal muscle oxygenation as determined by near-infrared spectroscopy. Our data suggest that muscle ischemia contributes to the augmented exercise pressor reflex in peripheral artery disease.  Please see the citation on the Research tab.

Dr. Muller's student receives prestigious research award from Penn State College of Medicine

posted Mar 19, 2017, 8:45 PM by Annie Muller

Alvaro Vargas Pelaez has been named the recipient of the 2017 Howard E. Morgan Award, for Outstanding Achievement in Basic Research.  Alvaro, a 4th year medical student working under Dr. Muller, will receive this award for his Medical Student Research project titled- Effect of adrenergic agonists on coronary blood flow: a laboratory study in healthy volunteers.  This Award was established in 1988 in honor of Howard E. Morgan, M.D., the founding Chair of the Department of Physiology at the Penn State College of Medicine. 


Congrats Alvaro !

Esmolol manuscript accepted for publication in the Journal of Applied Physiology.

posted Jan 14, 2017, 1:18 PM by Annie Muller

We used cycle ergometry exercise and infusions of isoproterenol and epinephrine to test the heart rate- lowering effect of esmolol compared to propranolol and saline in healthy humans. Collectively, our data indicate that infusing ~160 mg of esmolol (range 110 to 200 mg in the 5 minutes prior to exercise) acutely and selectively blocks β1 adrenergic receptors. These infusion parameters can be used in future experiments to evaluate β1 versus β2 control of the circulation in humans. 


The full article can be found at: https://www.ncbi.nlm.nih.gov/pubmed/28035016

Functional MRI experiment published in Physiological Reports

posted Nov 3, 2016, 6:04 PM by Annie Muller

In this human exercise physiology study, three different imaging modalities (ultrasound of the popliteal artery, blood-oxygen-level-dependent magnetic resonance imaging, and near infrared spectroscopy) evaluated calf muscle microvascular physiology during exercise. Blood-oxygen-level-dependent signal intensity in the gastrocnemius muscle decreased at higher workloads despite greater popliteal blood flow, indicating improved oxygen extraction. The full article can be found at: https://www.ncbi.nlm.nih.gov/pubmed/27798357

Coronary blood flow article in Physiological Reports chosen for podcast

posted Aug 6, 2016, 5:57 PM by Annie Muller

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Editor-in-Chief Susan Wray and Dr. Muller discussed a recently published article in Physiological Reports.  The first author of this paper is medical student Alvaro Vargas Pelaez and the podcast can be accessed here:

https://www.youtube.com/watch?v=mg7iwDllK0g&feature=youtu.be

Dr. Muller celebrates trainee publications at laboratory dinner.

posted May 22, 2016, 6:20 PM by Annie Muller

Muller Lab Students
On Wednesday May 18th, laboratory members (left to right) Amanda Ross, Alvaro Vargas Peleaz, Matt Heffernan, Carter Luck, Stephan Maman, Dr. Matt Muller, and Hardikkumar "Henry" Patel had dinner at Houlihan's Hershey to celebrate their numerous publications over the past 4 years. They also discussed future directions for research.  Missing from this photo are Brittney Randolph (former undergraduate intern), Jon Pollock (currently 2nd year internal medicine resident at Wright-Patterson Air Force Base), and Nate Winkler (2nd-year medical student at Central Michigan).

Dr. Muller gave symposium lecture at Experimental Biology 2016 on Wednesday April 6

posted Mar 30, 2016, 7:18 PM by Annie Muller   [ updated Apr 13, 2016, 7:26 PM ]

EB 2016
The title of this 25-minute presentation was "Aging Modifies Reflex Cardiovascular Responses to Local and Systemic Cold Exposure".  Dr. Zac Schlader from the University at Buffalo and Dr. Daniel Gagnon from UT Southwestern organized this symposium.

The Third Annual Faculty vs Residents softball game was held Sunday, October 4, 2015.

posted Oct 8, 2015, 4:20 PM by Annie Muller   [ updated Oct 8, 2015, 4:21 PM ]

Once again, the Faculty team was victorious over the Resident team.
 
Final score:
Faculty - 10
Residents - 5

 
Although the weather did not look like it would cooperate, the sun made its appearance before the first pitch. 
 
There was great faculty and resident turnout and everyone had a fun filled afternoon.
 
Thank you to all those who supported our teams.
 
Rumor has it the Resident team is already demanding a rematch.
 
 
Stay tuned for more information on a Springtime ball game.


Matt Muller named to Editorial Board of AJP: Regulatory, Integrative, Comparative.

posted Aug 10, 2015, 6:40 PM by Annie Muller   [ updated Aug 10, 2015, 6:40 PM ]

APS logo
Matt Muller named to Editorial Board of AJP: Regulatory, Integrative, Comparative.

http://ajpregu.physiology.org/edboard

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