Here you will find an archive of news and announcements I have had over my career.

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Dr. Muller gives career seminar at Miami University in Oxford, Ohio.

posted Mar 19, 2019, 6:43 PM by Annie Muller

Dr. Muller gives career seminar at Miami University
On March 7, Dr. Muller travelled to Oxford, Ohio and presented a seminar hosted by the Department of Kinesiology and Health.  He discussed his own personal non -linear career path and offered career advice to undergraduate and graduate students. 

Graduate student publishes MSNA paper in Physiological Reports.

posted Feb 7, 2019, 11:26 AM by Annie Muller

MSNA azakelj
Amanda Miller, a graduate student working under the guidance of Dr. Larry Sinoway and Dr. Muller, recently published a paper showing that young women have paradoxical vasodilation to the cold pressor test. This supports an emerging body of literature that suggests that young women have attenuated vasoconstriction or enhanced vasodilation to physiological stressors.

Dr. Muller gives lecture about CAA profession to high school students.

posted Dec 12, 2018, 5:24 PM by Annie Muller

Dr. Muller at St. FrancisSt. Francis de Sales High School in Toledo hosted a career discovery night on Wednesday December 5.  Dr. Muller volunteered to talk to groups of students and parents about the undergrad and graduate school coursework to become a Certified Anesthesiologist Assistant and the pros and cons of this career.

Dr. Muller collaborative R21 grant with Dr. David Proctor funded by National Institutes of Health.

posted Nov 12, 2018, 5:44 PM by Annie Muller   [ updated Nov 12, 2018, 5:48 PM ]

brachial aZakelj
September 2018: Peripheral artery disease (PAD) is highly prevalent in older adults and is characterized by impaired walking tolerance and high risk of cardiac death. In this T1 translational project we will conduct mechanism-driven intervention studies to test how beta-1 blockade (Aim 1) and dietary nitrate supplementation in beetroot juice (Aim 2) impact walking tolerance and coronary blood flow in PAD patients age 55 to 85.

Dr. Muller starts new job at University Hospitals Cleveland Medical Center.

posted Nov 12, 2018, 5:42 PM by Annie Muller   [ updated Nov 12, 2018, 5:49 PM ]

University HospitalsJuly 2018: Dr. Muller starts new job at University Hospitals Cleveland Medical Center.

Coronary manuscript written by medical student Stephan Maman published in the Journal of Applied Physiology.

posted Aug 12, 2017, 5:38 AM by Annie Muller   [ updated Aug 12, 2017, 5:44 AM ]

In this study, we evaluated the role of vascular β1 vs. β2 receptors in coronary exercise hyperemia in a single-blind, randomized, crossover study in healthy men. In response to isometric handgrip exercise, blood flow velocity in the left anterior descending coronary artery was significantly greater with esmolol compared with propranolol. These findings increase our understanding of the individual and combined roles of coronary β1 and β2 adrenergic receptors in humans. Please see the citation on the Research tab.

Near infrared manuscript written by J. Carter Luck published in the Journal of Applied Physiology.

posted Jul 22, 2017, 10:31 AM by Annie Muller

In this laboratory study, patients with peripheral artery disease performed plantar flexion exercise in the supine posture until symptoms of claudication occurred. Relative to age- and sex-matched healthy subjects we found that patients had a higher blood pressure response, a higher heart rate response, and a greater reduction in skeletal muscle oxygenation as determined by near-infrared spectroscopy. Our data suggest that muscle ischemia contributes to the augmented exercise pressor reflex in peripheral artery disease.  Please see the citation on the Research tab.

Dr. Muller's student receives prestigious research award from Penn State College of Medicine

posted Mar 19, 2017, 8:45 PM by Annie Muller   [ updated Nov 12, 2018, 6:26 PM ]

Alvaro Vargas Pelaez has been named the recipient of the 2017 Howard E. Morgan Award, for Outstanding Achievement in Basic Research.  Alvaro, a 4th year medical student working under Dr. Muller, will receive this award for his Medical Student Research project titled- Effect of adrenergic agonists on coronary blood flow: a laboratory study in healthy volunteers.  This Award was established in 1988 in honor of Howard E. Morgan, M.D., the founding Chair of the Department of Physiology at the Penn State College of Medicine. 

Congrats Alvaro !

Esmolol manuscript accepted for publication in the Journal of Applied Physiology.

posted Jan 14, 2017, 1:18 PM by Annie Muller

We used cycle ergometry exercise and infusions of isoproterenol and epinephrine to test the heart rate- lowering effect of esmolol compared to propranolol and saline in healthy humans. Collectively, our data indicate that infusing ~160 mg of esmolol (range 110 to 200 mg in the 5 minutes prior to exercise) acutely and selectively blocks β1 adrenergic receptors. These infusion parameters can be used in future experiments to evaluate β1 versus β2 control of the circulation in humans. 

The full article can be found at:

Functional MRI experiment published in Physiological Reports

posted Nov 3, 2016, 6:04 PM by Annie Muller

In this human exercise physiology study, three different imaging modalities (ultrasound of the popliteal artery, blood-oxygen-level-dependent magnetic resonance imaging, and near infrared spectroscopy) evaluated calf muscle microvascular physiology during exercise. Blood-oxygen-level-dependent signal intensity in the gastrocnemius muscle decreased at higher workloads despite greater popliteal blood flow, indicating improved oxygen extraction. The full article can be found at:

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