Article Accepted

Sept 18, 2012 Muller MD, Drew RC, Blaha CA, Mast JL, Cui J, Reed AB, Sinoway LI. Oxidative stress contributes to the augmented exercise pressor reflex in peripheral arterial disease patients. J Physiol. IN PRESS, accepted 09/18/12

In this study, we demonstrated that mechanically sensitive muscle afferents cause augmented reflex elevations in BP during dynamic plantar flexion exercise in peripheral artery disease patients. These responses occurred prior to claudication pain, were related to disease severity, and were partly reduced by acute antioxidant infusion.